Summary: Painful period/dysmenorrhoea is defined as the feeling of painful cramps in the lower abdomen of varying intensity that appear several hours before or just after menstruation and last up to 48–72 hours. Dysmenorrhoea can be divided into primary and secondary. Primary proceeds without pathologies of the reproductive system. However, the underlying cause of secondary dysmenorrhea is pelvic pathology. Dysmenorrhoea, or painful period, is the most common gynecological disease among young women. Spasmolytics (primarily drotaverine) when used alone or in combination with nonsteroidal anti-inflammatory drugs (NSAIDs) have a beneficial therapeutic effect.