Summary: Cholelithiasis is a significant problem in the healthcare system, especially in the elderly population. Elements of prevention of gallstones should include a healthy lifestyle, a well-balanced diet, systematic consumption of meals, regular physical activity, taking vitamin C, normal body weight (normal BMI, body mass index). Ursodeoxycholic acids (UDCA) are used in pharmacological treatment. Examples of contraindications for dissolution include increased symptoms of urolithiasis, malabsorption syndrome, pregnancy, chronic cholecystitis, some liver diseases, pigmented deposits, calcified deposits, deposits with a diameter > 1.5 cm. Although symptomatic urolithiasis accounts for less than 20% of cholelithiasis cases in general, it leads to serious complications as well as increasing the cost of medical care. Prevention of cholelithiasis is very important.