Summary: Nonmelanoma skin cancers are among the most common malignant neoplasms in humans. The risk of developing them increases with age, and in people with fair skin it reaches 20% throughout the life. We observe a steady increase in the incidence of these cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma. Other types of skin cancers are rare. Merkel cell carcinoma is a special type of very aggressive skin cancer, which requires prompt diagnosis and treatment. Most skin cancers are successfully treated surgically, and the currently used methods allow 99% of patients to be cured. However, in a few cases, the disease recurs and / or progress and does not qualify for local treatment with surgery or radiation therapy, and systemic treatment is necessary. This manuscript describes novel methods of treatment of nonmelanoma skin cancers, including inhibitors of the Hedgehog pathway in squamous cell carcinoma and checkpoint inhibitors in squamous cell carcinoma, basal cell carcinoma and Merkel cell carcinoma. The directions of current clinical trials in nonmelanoma skin cancers are also discussed.