Summary: Atopic dermatitis is a common skin disorder of infancy. Despite its name, the influence of atopy and food allergy seems to be marginal. In this review we concentrated on concise overview of EuroGuiDerm 2022 guidelines and practical approach to treatment. In general, skin moisturizers and anti-inflammatory treatment should be used for obtain a fast and effective remission. Anti-inflammatory treatment should rely on tacrolimus ointment or local glucocorticoids application. We underlying the safety and efficacy of calcineurin inhibitors in atopic eczema treatment. Recently, several biologicals became a treatment option in the most severe patients.