Summary: The synergistic action of vitamins B1, B6, B12 makes their role essential for the proper functioning of both the central and peripheral nervous system, in prevention and treatment of many pathologic conditions. They form a biochemical synergy in many different pathways in the nervous system, regulate cellular metabolism, energetic processes, glucose and carbohydrate metabolism, stimulate myelin regeneration, improve nerve conduction. They are effective in polyneuropathies, anemia, dementia, but also have an important neuroprotective and antiepileptic role, improve learning and memory and have an anti-depressive effect.
Important role in homocysteine metabolism, protecting from arteriosclerosis and dementia, important in proper development of the nervous system. Important role at all ages; underestimated in young and old patients with relative deficiency. Relative deficiency of vitamins B1, B2, B12 becoming more common in present times. Should be considered as complex treatment for many peripheral neuropathies and many brain disorders. Very effective in the treatment of different types of neuropathy, in metabolic disorders and cardiac failure, as main treatment and adjunctive therapy; important in prophylaxis of many metabolic disorders in children and adults.