General practice Terapia 2019, 6 ( 377 ) : 31 - 40
Technological differences between selected medicinal products containing nebivolol
Summary:
Tablets are a crucial form of a drug in pharmacotherapy. As a dosage form of a drug, tablets contain a precise dose of a biologically active substance. Usually, tablets are an indivisible composite. Only in justified cases is it possible to divide tablets into smaller parts, halves or quarters. This is the case for some medicinal substances, which is due to their therapeutic properties. The possibility of division into smaller parts is clearly and strictly defined in the guidelines of the XI Polish Pharmacopoeia. An individual approach of doctors, pharmacists or patients can’t affect the way tablets are divided. According to those guidelines, it is a duty holder that decides on the possibility of a tablet’s division at the stage of the product’s development. Furthermore, this possibility should be properly documented and it relates to two situations solely: a division into smaller parts to make it easier to take the tablet and the division in order to apply a half or a-quarter of the total dose to the patient. This second case is very important, because if a patient divides the tablet, the patient divides a dose of medicinal substances at the same time. In this work, research has been conducted on an assessment of a morphology of the tablets with nebivolol and on an impact of these parameters on the properties related to the division.
Keywords: nebivolol, tablets, division of tablets into parts, hardness of tablets, auxiliary substances, disintegration time of tablets
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