Summary: In times of widespread availability and frequent use of various types of pharmacological supplementation, it is extremely important to reach for preparations with proven effective scientific action. This is particularly important when planning comprehensive treatment in patients with cardiovascular disease, including heart failure. Coenzyme Q10 is a substance that has a well-proven antioxidant effect as both an antioxidant and an electron acceptor at the mitochondrial level. Numerous clinical studies have been conducted to assess the effectiveness of coenzyme Q10 in the treatment of cardiovascular disorders related to aging, including chronic heart failure, hypertension and endothelial dysfunction. There are reports showing that coenzyme Q10 may be an effective therapeutic option to supplement the treatment of these diseases, and for example in patients with heart failure may significantly improve the clinical prognosis.