Summary: Hypertension is frequently diagnosed among hemodialysis patients with chronic kidney disease (CKD) and often remains poorly controlled. Volume overload is the main factor contributing to the pathogenesis of hypertension in these patients. Hemodialysis patients with CKD are characterized by higher blood pressure variability than the general population. Therefore, in the diagnosis and monitoring of hypertension in these patients, self-measurement of blood pressure at home done during the days between hemodialysis sessions should be preferred. The target values of blood pressure in hemodialysis patients with CKD are still a matter of debate. However, self-measured systolic blood pressure values at home between 120 to 130 mm Hg are associated with the best prognosis in these patients. Among non-pharmacological methods of antihypertensive treatment in hemodialysis patients with CKD, reducing volemia by increasing ultrafiltration during hemodialysis procedures, individualization of sodium concentration in the dialysis fluid and a low sodium diet should be mentioned. In antihypertensive pharmacotherapy, b-adrenergic antagonists seem to be preferred.