Summary: Pain, especially musculoskeletal pain, is one of the basic symptoms leading to consultations in general practice. Chronic pain syndromes lead to complications and significant reduction in the quality of life of patients. The development of osteoarthritis, rheumatoid arthritis and shingles is correlated with the age of patients and pain is the main symptom of those diseases. The pharmacotherapy of pain should be based on an individualized choice of medication. Properly carried out analgesic treatment ensures patients’ comfort of life.