Summary: Shingles is an infectious disease caused by varicella zoster virus. Following active phase of chicken pox and crusting of skin lesions the virus spreads to the spinal and the cranial ganglia where it can stay dormant for many years. In immunocompromised patients the virus can become active leading to shingles. Shinglesʼ incidence is about 3‒4 cases per 1000 and rises abruptly with age. It is estimated that 10‒20% of human population will become sick with shingles. The dominant symptom in the acute phase of the disease is burning pain accompanied by impairment of cutaneous sensation. Vesicles desquamate usually by 3‒5 weeks if they do not become secondarily infected. In some patients (9‒15%) after healing of the skin lesions the pain can persist in the form of chronic pain syndrome at various intensity levels, usually semi-lateral within one or several dermatomes or the trigeminal nerve (1). In this papers there have been described risk factors PHN, prophylactic measures and methods of treatment of chronic post herpetic neuralgia according to evidence based medicine.