Summary: Opioids are an important group of analgesics that are well-established in relieving pain. They are characterized by good, dose-dependent analgesic efficacy, as well as the entire spectrum of side effects, including sedation, nausea, vomiting, gastrointestinal motility disorders, itchy skin, urinary retention or respiratory depression. They can also cause immunosuppression, hyperalgesia, or dependence. Therefore, the currently recommended strategy for pain management is multimodal analgesia, which consists in combining drugs and techniques with diff erent mechanisms of action. Due to the addition or synergism of drugs and methods used in multimodal therapy, it is possible to satisfactorily control pain and eliminate or signifi cantly reduce the doses of opioids required for use. Currently, many experts propose opioid-free analgesia regimens (OFA) especially dedicated to selected groups of patients (e.g. patients with extreme obesity, COPD and sleep apnea, cancer patients, immuno-suppressed patients, chronic pain patients, opioid addicts). The presented work discusses the assumptions of OFA, its individual components and current views on its application in clinical practice.