Summary: Deep venous thrombosis (DVT) needs confirmation. When DVT is confirmed, anticoagulation is indicated. Anticoagulation may consist of a parenteral anticoagulant overlapped by vitamin K antagonists (VKA) – warfarin and acenocumarol or followed by a direct oral anticoagulant (DOAC) (dabigatran or edoxaban), or of a DOAC (apixaban or rivaroxaban) without initial parenteral therapy. DOACs are the preferred method of treatment for DVT. Sulodexide seems to be very good alternative for prolonged teatment of recurrent DVT when 3–6 months long term treatment is achieved and risk of recurrent DVT is high, as well as bleeding risk.