Summary: Pruritus, accompanied by dry skin, is the most common skin symptom in patients over 65 years of age. This manifestation requires a comprehensive clinical approach, carrying out a detailed medical interview, physical examination, and laboratory tests. The symptoms of pruritus and dry skin may be potentially devastating and significantly reduce their quality of life. Population-based studies show that one in five people in the general population has suffered from chronic pruritus at least once in their lifetime, with a prevalence of 7% over 12 months. Pruritus can result from both dermatological and non-dermatological diseases. Very often, in the case of non-dermatological skin, it can be caused by systemic diseases, e.g. neurological or psychiatric, and may also be an adverse effect of various medications. In many cases, pruritus may have a multifactorial origin. Treatment of pruritus and dry skin includes treatment of the underlying disease and implementation of topical treatments, including antipruritic medication, phototherapy, and systemic treatment. The treatment of pruritus and dry skin must be targeted and managed in a stepwise manner, requiring a multidisciplinary approach to the patient. The article presented below is intended to assist you in selecting appropriate and effective therapeutic management for people struggling with pruritus and dry skin.