Summary: Vaccinations represent an effective and largely safe method for preventing infectious diseases in older individuals. The elderly are a particularly vulnerable demographic to experience more severe and complex infections due to the presence of multiple chronic diseases.. Despite the weaker immune response, vaccination schedules for the elderly mostly do not differ from those used for adults in younger age groups (with the exception of the tick-born encephalitis vaccine, where a booster dose is given to individuals over 60 years more frequently than to younger individuals, (i.e., every 3 years). Significant emphasis should be placed on vaccinations against influenza, pneumococcal disease, and, more recently, COVID-19, as these pathogens are the most prevalent and are associated with higher mortality rates in the older population. The introduction of COVID-19 vaccinations has notably reduced hospitalizations among individuals aged 65 and older. Innovative developments for the elderly include the conjugated vaccine PCV20, the one-time administration of which replaces the previously recommended schedules involving the administration of PCV13 and, after 12 months, PPSV23. Other new vaccines include a vaccine against herpes zoster and against RSV. In the elderly population, a higher risk of adverse post- -vaccination reactions only pertains to yellow fever vaccinations.